Had to post this on the 4th day of the 4th month on 4 different websites after for the sake of this joke. Hear me out. Think about how they treated any franchise that wasn't American at that time. They would try to Americanize the hell out of it, at the same time, keep all the flair and craziness of jojo.
Also, I you think about it for a minute. If Jojo's bizarre adventure truly blew up in the USA and they made a movie or 3 of part 5, Chris Tucker would make the perfect Guido Mista. And I have 4 main reasons to support this claim.

1. His mannerisms: given how Mista acts, it only makes sense to have someone who is extra exaggerated play him. I have a feeling his take on Mista would be a mix of the flamboyant reporter from the 5th element and the cop from rush hour. Plus, he is the only one of the protagonists that uses a gun, which ends up backfiring on hi in some way shape or form. Not to mention the extra flare he'd put into the poses, and the torture dance.

2. Sex pistols. Each pistol has a distinct personality that Tucker could voice and act out to his fullest potential. Not to mention the fact they all pick on #5(which is technically #4) is comedy gold.

3. The fact he switched bodies with Trish (the daughter of the boss). Chris Tucker is no stranger to playing flamboyant characters, and him acting as a teenage girl stuck in his body works way too well.

4. His overall fear of the number 4. There is soooooooooo much to work with that. In the show and Manga, Mista believes picking anything from 44 or the number 4 itself is and luck, and to his credit, that has reigned true is this show, and Chris Tucker would make sure to let people now he was right.

Hell, even his name, Guido Mista, is 4 syllables.